Importantly, we found that their co-enriched KEGG pathway analysis was mostly related to “insulin signaling pathway”, “insulin resistance”, and “type II diabetes mellitus”, which undoubtedly indicated the specific characteristics of brown adipose tissue in sEV-BAT lncRNAs, as a high engagement in metabolism, insulin related signaling, and diabetes related pathways. The gene discussed is INS; the disease is type 2 diabetes mellitus.