TP53 and neoplasm: p53 induces nuclear paraspeckle assembly by directly upregulating the scaffold lncRNA nuclear‐enriched abundant transcript 1 (NEAT1) in response to various oncogenic stimuli.[115, 116] The paraspeckles act as tumor suppressors downstream of p53 to prevent early‐stage neoplasia.[115] During tumor progression, paraspeckles are involved in chemoresistance, wherein NEAT1 promotes ataxia telangiectasia and Rad3‐related (ATR) signaling activation in response to replication stress.