In contrast to regular enhancers, bromodomain‐containing 4 (BRD4) and MED1 co‐occupy thousands of enhancers (i.e., SEs) associated with active oncogenes, including MYC.[241] Homeobox B8 (HOXB8) and FOS‐like 1 (FOSL1), which are master TFs of core regulatory circuitry (CRC), mediate liquid‐like puncta formation of CRC in cell nuclei. The gene discussed is HOXB8; the disease is colorectal carcinoma.