eMI contributes to clearance of prone‐to‐aggregate proteins such as Tau; however, pathogenic Tau variants found in Tauopathies fail to be degraded by eMI and instead hinder this type of autophagy by promoting docking of LE/MVBs in the plasma membrane and subsequent release of the pathogenic Tau variants (Caballero et al., 2018; Caballero et al., 2021). Here, MAPT is linked to tauopathy.