PPARG and hepatocellular carcinoma: Consistent with TGF-βRI knockdown in SNU449 hepatocellular carcinoma cells, decreased levels of sphingolipids and phospholipids have been detected together with decreased expression of fatty acid synthesis genes, such as acyl CoA synthetase 5 (ACSL5) and peroxisome proliferator-activated receptor gamma (PPARγ) [98].