Inhibition of the TGF-β pathway through knockdown of TGF-βRI in hepatocellular carcinoma SNU449 cells correlates with reduced expression of PPP-related genes, including G6PD, hexose-6-phosphate dehydrogenase, and 6-phosphogluconolactonase [98]. The gene discussed is TGFB1; the disease is hepatocellular carcinoma.