Cancer cell-derived TGF-β cytokines trigger TGF-β non-canonical p38-MAPK signaling via paracrine signaling, which stimulates the production of several cytokines from CAFs that induce glycogen metabolism upregulation in cancer cells via phosphorylation and activation of phosphoglucomutase 1, an enzyme involved in glycogenesis. Here, TGFB1 is linked to cancer.