In DLBCL patients who completed 3 cycles of (R)-CHOP chemotherapy, HDL-C was not better than NT-proBNP in predicting AISC, but their combined use provided an elevated prognostic value (area under curve [AUC] = 0.752, P = 0.001 vs. HDL-C; AUC = 0.631, P = 0.068 vs. NT-proBNP; AUC = 0.640, P = 0.054). The gene discussed is NPPB; the disease is diffuse large B-cell lymphoma.