Moreover, T1DM cause protracted disease onset which is associated with immune system and thus, the destruction was ensued by 80% of β-cells in the islets of pancreas [12], which eventually effects the insulin uptake to acquire the following conditions i.e., hyperglycemia [13], hyperlipidemia, inflammation, oxidation [6] and insulitis [4]. This evidence concerns the gene INS and Hyperglycemia.