INS and type 1 diabetes mellitus: Notably, oral administration of different CDDP doses (DDP-Low, DDP-Med and DDP-High) to STZ-induced T1DM mice had showed an improvement in the levels of serum insulin, HOMA-IR and partially restored the loss of β-cell by elevating the levels of HOMA-β-cell indicating a significant rise in insulin secretion and indicated a dose-dependent effect of crude polysaccharide (CDDP).