On the basis of their functional ability several natural plants such as seaweeds, contain variety of nutrients that are suitable for consumption and its polysaccharides isolated from different plant sources had showed a promising outcome than the standard available drugs to treat diabetes complications such as lowering fasting glucose levels by enhancing insulin secretion, promotes and escalates the growth of intestinal gut microbiota, increases volume of stool and reduces the overall risk of colon cancer in STZ-induced T1DM animals [42, 50, 59–62]. This evidence concerns the gene INS and diabetes mellitus.