In model 3 with the maximum covariates including age, sex, APACHE II score, PaO2/FIO2,vasopressor use, CRRT, CKD, AKI, septic shock, albumin, creatinine, leukocyte, and CRP, adjusted HR for in-hospital mortality was 2.640 (95%CI, 1.208–5.767,P = 0.015). This evidence concerns the gene ALB and septic shock.