HFE and Tangier disease: Also, it should be pointed out the risk of iron overload when an iron-replete woman or those with mutations in the HFE gene –which increases the intestinal iron absorption, especially in homozygotes but also in heterozygosis to a lesser extent– receives routine prenatal iron supplements [29–31], as well as the negative consequences that have also been associated with prenatal excess iron on the neuropsychological functions of the child [14, 22, 25, 32, 33].