Furthermore, levels of E-cadherin expressions in the same tissue specimens of OSCC was also found significantly down regulated (Fig. 2b, Table 5) as compared to controls but when the two proteins were correlated with each other, no significant correlation could be observed between the two except in the region of tumor periphery (Fig. 6), where a negative correlation could be observed between the two proteins. Here, CDH1 is linked to neoplasm.