DM might be mediated by binding of insulin-like growth factor-1 (IGF-1) to the IGF-1 receptor and activate mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase/protein kinase B (PI3K/AKT) signaling pathways leading to increased cell proliferation and decreased apoptosis [41]. Here, WNK2 is linked to diabetes mellitus.