To identify whether the difference in valvular lipid accumulation between Apoe−/− and Ldlr−/− mice originated from differences in scavenger receptor expression levels, we examined the average expression levels of scavenger receptors and the level of each scavenger receptor (Msr1, Scarb1, Orl1, and Cd36) associated with LDL, via transcriptomic analysis of the whole aortic valve tissue, using five different experimental groups (C57BL/6J chow mice, Apoe−/− chow and WD mice, and Ldlr−/− chow and WD mice). This evidence concerns the gene MSR1 and Wilson disease.