Consistent with results in vitro, tumors generated from cells transfected with LV-circSEMA4B, LV-circSEMA4B-MUT, and LV-circSEMA4B-211aa had smaller size (Fig. 8c, d) and lower weight (Fig. 8e) compared to the LV-circSEMA4B-NC group, indicating that overexpression of circSEMA4B and SEMA4B-211aa dramatically attenuated tumor growth. Here, SEMA4B is linked to neoplasm.