Meanwhile, AKT upregulates SHKBP1 expression, enhancing EGFR activity.381 In HCC, upregulation of miRNA-125-5p suppressed ataxin-1 expression and induced Snail-mediated EMT, enhancing cancer cell stemness and leading to sorafenib resistance.382 In addition, miR-424 could target chromo box 4 (CBX4) to induce YAP nuclear translocation, which enhances tumor stemness and sorafenib resistance.383 Additionally, tumor cells can release miRNAs from exosome to TME and convey resistance to other cells. This evidence concerns the gene SHKBP1 and neoplasm.