Low expression of TIP30 is associated with gefitinib resistance in NSCLC cell lines, while upregulation of TIP30 improves drug resistance by attenuating EGFR signaling pathway.198 In NSCLC cell lines, TKI-bounded EGFR can dimerize with other RTKs like HER and AXL to promote nuclear translocation of protein kinase C δ (PKCδ), a member of the PKC family.199 Nuclear PKCδ phosphorylates key nuclear proteins to regulate apoptosis. This evidence concerns the gene PRKCD and non-small cell lung carcinoma.