CBX4 and neoplasm: Meanwhile, AKT upregulates SHKBP1 expression, enhancing EGFR activity.381 In HCC, upregulation of miRNA-125-5p suppressed ataxin-1 expression and induced Snail-mediated EMT, enhancing cancer cell stemness and leading to sorafenib resistance.382 In addition, miR-424 could target chromo box 4 (CBX4) to induce YAP nuclear translocation, which enhances tumor stemness and sorafenib resistance.383 Additionally, tumor cells can release miRNAs from exosome to TME and convey resistance to other cells.