Apart from miRNAs, other ncRNAs like lncRNAs and circRNAs are associated with TKI-related drug resistance.393 In sunitinib-treated RCC, lncRNA-ECVSR can enhance the stability of estrogen receptor beta (Erβ) mRNA to upregulate HIF-2α transcription, promote vascular mimicry, cancer stemness, and RCC progression.394 LncRNA-CASC9 suppresses DUSP1 expression by recruiting histone methyltransferase enhancer of zeste homolog 2 (EZH2). The gene discussed is ESR2; the disease is renal cell carcinoma.