In HCC, HOXB cluster antisense RNA 3 (HOXB-AS3) interacts with EZH2 to recruit EZH2 to the Dicer’s promoter to add H3K27me3 modification, leading to Dicer transcriptional repression, resulting in the acquisition of stem cell-like properties and sorafenib resistance.414 Dicer is an RNase III nucleic acid endonuclease in the cytoplasm that is essential for mRNA maturation. This evidence concerns the gene EZH2 and hepatocellular carcinoma.