Inhibition of GPX4 is an effective method to target the intrinsic pathway.333 Inhibition of GPX4 could overcome the EGFR-TKI resistance by inducing ferroptosis in NSCLC and LUAD cell lines.331,334 Reducing GSH precursor uptake, increasing intracellular ferric ion concentration, and increasing ROS levels are helpful for extrinsic pathways. Here, EGFR is linked to non-small cell lung carcinoma.