FLT3 and chronic myelogenous leukemia, BCR-ABL1 positive: Cannabidiol exerts a synergistic effect with imatinib in imatinib-resistant CML cells.354 In AML carrying FLT3-ITD, FLT-3-ITD molecules were detected in the autophagosome after induction of autophagy with the proteasome inhibitor bortezomib.