MT-1G is a ROS scavenger that negatively regulates ferroptosis.320,322–324 ABCC5 stabilizes SCL7A11 to increase GSH precursor uptake and simultaneously enhance sorafenib efflux, leading to TKI resistance.325 Apart from NRF2 pathways, the Hippo pathway downstream transcriptional complex YAP/TAZ (Tafazzin)-TEAD (TEA domain transcription factor) is a key factor for sorafenib resistance in HCC. This evidence concerns the gene TAFAZZIN and hepatocellular carcinoma.