The contradictory results regarding the role of autophagy in TKI resistance reflect the uncertain role of autophagy in cancer treatment.357 Therefore, some concerns require further exploration: (I) the relationship between abnormal PTK activation and autophagy; (II) whether all TKIs induce autophagy and how to define the protective and toxic effects of TKI-induced autophagy on cancer cells. The gene discussed is PTK2B; the disease is cancer.