GPX4 and non-small cell lung carcinoma: Inhibition of GPX4 is an effective method to target the intrinsic pathway.333 Inhibition of GPX4 could overcome the EGFR-TKI resistance by inducing ferroptosis in NSCLC and LUAD cell lines.331,334 Reducing GSH precursor uptake, increasing intracellular ferric ion concentration, and increasing ROS levels are helpful for extrinsic pathways.