E2F1 and gastrointestinal stromal tumor: IL-6 overexpression results in LUAD resistance.397 High lncRNA-RP11616M22.7 are associated with imatinib resistance in GIST, which may lie in the regulation of the hippo pathway by Ras association domain family member 1 (RASSF1).398 As for circRNA, sorafenib induces circFN1 and circFOXM1 expression in HCC, thereby promoting E2F transcription factor 1 (E2F1) and methyl-CpG binding protein 2 (MECP2) expression through circFN1/miR-1205/E2F1 and circFOXM1/miR-1324/MECP2 pathways.