SMYD2 and nonpapillary renal cell carcinoma: Additionally, deletion of lysine methyltransferase 5 C (KMT5C), an HMT responsible for histone H4 lysine 20 trimethylation (H4K20me3), upregulates lncRNA-LINC01510 and promotes MET transcription, leading to EGFR-TKI resistance in NSCLC through activation of the bypass pathway.415 SET and MYND domain containing 2 (SMYD2) are highly expressed in ccRCC, and associated with multidrug resistance, including sunitinib in RCC.