NFKB1 and chronic myelogenous leukemia, BCR-ABL1 positive: LSD demethylates the NF-κB catalytic unit p65 to activate the NF-κB pathway in an HDAC5-dependent manner, resulting in cell survival.419 In addition, upregulated lysine demethylase 6 A (KDM6A) in CML can be recruited to the NTRK1 promoter by the transcription factor YY1.