DICER1 and hepatocellular carcinoma: In HCC, HOXB cluster antisense RNA 3 (HOXB-AS3) interacts with EZH2 to recruit EZH2 to the Dicer’s promoter to add H3K27me3 modification, leading to Dicer transcriptional repression, resulting in the acquisition of stem cell-like properties and sorafenib resistance.414 Dicer is an RNase III nucleic acid endonuclease in the cytoplasm that is essential for mRNA maturation.