DUSP1 and colorectal carcinoma: Consistently, TSPYL5 inhibition improves drug resistance.134 The reasons for the low expression of DUSP1 and PHLPP have not been found, but it was elucidated that high expression levels of miR-452-5p in CRC can negatively regulate DUSP1 and lead to apoptosis resistance, suggesting a role of epigenetics in its regulation.135 Thus, low expression of negative regulators can be reversed by epigenetics manipulation.