MBD2 and gastric cancer: For example, increased miR-424 levels induced CBX4 depolymerization to reduce YAP1 nuclear translocation, and improved sorafenib resistance.383 MiR-210-5p antagomir in combination with sorafenib alleviated sorafenib resistance.347 In addition, paeonol inhibits proliferation and promotes apoptosis of apatinib-resistant gastric cancer cells via lncRNA-00665/miR-665/MAPK1 axis.408 CircKCNN2 upregulates methyl-CpG binding domain protein 2 (MBD2) via miR-520c-3p.