ERBB2 and breast carcinoma: Inhibition of SREBP1 elevates ROS and lipid peroxidation levels, suggesting that SREBP1-induced de novo synthesis of fatty acids can prevent cell death.289 However, in HER2-TKI lapatinib-resistant breast cancer cell lines, lapatinib upregulated CD36 to increase exogenous fatty acid uptake instead of fatty acid de novo synthesis.