Among the 58 invasive ductal carcinoma specimens, nearly half of the samples (44.8%, 26/58) displayed a reduced SPOP expression along with increased TWIST1, whereas one-third (32.8%, 19/58) of tumors with higher SPOP had lower TWIST1 and 12.1% of tumors had no changes in either one (Fig. 1F). The gene discussed is SPOP; the disease is invasive ductal breast carcinoma.