MTOR and Miyoshi myopathy: Indeed, we observed that RAS, MTOR and SLC3A2 colocalized with LAMP1 in RPMI 8226 and SKMM1 MM cells ectopically expressing fluorescent fusion constructs of KRASG12D or NRASG12D (Fig. 4h, yellow arrows), demonstrating that SLC3A2, RAS and MTOR form a complex on LAMP1 + vesicles within MM cells.