Expression analysis of the Elvidge HIF-1α and HIF-2α signature in a cohort of glioblastoma patients (n = 152), available from The Cancer Genome Atlas (TCGA) [29], revealed a positive correlation between PFKFB4 expression (r = 0.657) and HIF signaling (Fig. 2C). Here, EPAS1 is linked to glioblastoma.