Further, ILC1s in chRCC, in contrast to ccRCC, selectively expressed high levels of granzyme A. In addition, NK cells and ILC1s showed an increased expression of the IL-2/IL-15 receptor β chain and chRCC tumors from TCGA cohort exhibited increased expression of IL-15, which is capable of enhancing anti-tumor responses.1 Here, IL15 is linked to chromophobe renal cell carcinoma.