The non-responding group of genes (including DHCR24, SNHG25, TRPM8, IFI6, FKBP2, PPDPF, HLA-DRA, TAGLN, TIMP1, AEBP1, IGFBP7, MGP, A2M, and CD74) has previously been described to correlate with e.g., androgen-independence, cell migration, resistance, PCa, cancer, tumor stroma, immune response, and inflammation61–74 (see Supplementary Tables 5–6 for complete list including downregulated genes). This evidence concerns the gene A2M and posterior cortical atrophy.