The association between peritumoral radiomics and EGFR mutations in our study is a reasonable result because peritumoral radiomics encompasses various aspects of PLC.9–16 For instance, Wu et al14 showed that peritumoral radiomics accurately differentiated adenocarcinoma in situ (AIS) or minimally invasive adenocarcinoma (MIA) from invasive adenocarcinoma. This evidence concerns the gene HSPG2 and androgen insensitivity syndrome.