EGFR and lung adenocarcinoma: Regarding the relationship between histology and EGFR status in lung adenocarcinoma, EGFR mutations are mainly observed in AIS, MIA, lepidic, and papillary types; solid and invasive mucinous types rarely show EGFR mutations.32 This is in line with our findings, where EGFR mutations were found in either lepidic predominant, papillary, or acinar types.