Based on the analysis of the TCGA CRC database (http://ualcan.path.uab.edu/analysis.html), we found that the mRNA levels of the vascular endothelial growth factor VEGFA and METTL3 in the CRC samples were high expressions (Fig. 1A, B), and METTL3 was significantly positively correlated with VEGFA (Fig. 1C). This evidence concerns the gene METTL3 and colorectal carcinoma.