In conclusion, our study demonstrates that METTL3 can dually regulate the stability of the LINC00662 and VEGFA RNAs to promote the angiogenesis in CRC.METTL3 and LINC00662 may both serve as early diagnostic and prognostic predictive biomarkers for CRC and potential targets for anti-vascular therapy as well. This evidence concerns the gene VEGFA and colorectal carcinoma.