Following this study, tau aggregates generated in vitro or isolated from brains of AD or other human tauopathies, and tau transgenic mice are reported to template tau aggregation in cultured cells18, 19 and to induce tau pathology in animal brains,20, 21, 22, 23, 24, 25 suggesting that aggregated tau serves as proteopathic tau seeds and may template tau aggregation in a prion‐like fashion. Here, MAPT is linked to Alzheimer disease.