We found that AD O‐tau induced hyperphosphorylation of tau in site‐specific manner (Figure 7A), which was attenuated at Ser262 or showed a reduction trend at Ser202/Thr205 (AT8 sites), Thr212, Thr217, and Ser422 in both hippocampi of mice with 77G7 iv‐injection (Figure 7A,B). The gene discussed is MAPT; the disease is Alzheimer disease.