We found that no AT8 positive cells in saline injected hippocampi, suggesting no tau pathology in the hippocampus of 12–14‐month‐old Tg/hTau mouse (Figure 6B), but a robust tau pathology was detected by AT8 staining in the ipsilateral and contralateral hippocampi of AD O‐tau injected mice (Figure 6B). This evidence concerns the gene MAPT and Alzheimer disease.