IGHE and allergic disease: Over the last decade, EWAS reported associations of single CpGs (addition of a methyl-group to a cytosine in the context of CpG dinucleotides) with several allergic outcomes: High total immunoglobulin E (IgE) [1, 2], an antibody involved in Type I immune response and highly associated with allergic diseases, specific IgE [3] against certain aeroallergens and specific IgE plus skin-prick test [4] and meta-analyses on asthma [5] and any allergic disease [6].