HSPA8 and systemic lupus erythematosus: In addition, it was also found that a defect in molecular chaperone-mediated autophagy (CMA) involving HSPA8 / HSC70, HSP90AA1 and lysosomal-associated membrane protein 2A (LAMP2A) was associated with SLE, and animal experiments showed that splenic LAMP2A expression was increased in purified B cells from lupus mice [24].