Volcano plot of the NF-PitNET phosphoproteins revealed β-catenin (CTNNB1 gene; p = 0.000016), Inter-alpha-trypsin inhibitor heavy chain H2 (ITIH2; p = 0.001) and Alpha-2-HS-glycoprotein (AHSG; p = 0.0006) as significantly more phosphorylated proteins in the recurrent tumours compared to the invasive NF-PitNET subgroup (Fig. 2b). This evidence concerns the gene ITIH2 and neoplasm.