We then went on to use a gene microarray analysis (21,448 genes) to profile the global gene regulation in cultured RA FLS (n = 3) treated with TNFα in the presence or absence of anti-TET3 small interfering RNA (siRNA) [i.e., TET3- knockdown (KD)] in an effort to determine whether TET3 mediates this TNFα induced transformation. This evidence concerns the gene TET3 and rheumatoid arthritis.