We searched for the downstream target genes of TET3 that might account for RA progression and successfully found that TET3 was required for the TNFα-mediated induction of 52 downstream genes including inflammatory factors and CXC-chemokines such as CCL2, CXCL5, and CXCL8 (Fig. 3A–C). The gene discussed is CXCL8; the disease is rheumatoid arthritis.