Micronuclei are recognized by specific PRR or cytoplasmic DNA sensors like cGAS [98, 99], and cGAS bound to micronuclei leads to STING activation, which is a pivotal player in promoting Type I Interferon and other immune genes [100] as silencing, deletion or chemically inhibition of STING abolished immune genes response in cancer cells (Fig. 3). The gene discussed is STING1; the disease is cancer.