It has been demonstrated by interactome analysis with mass spectrometry of breast cancer cells that a part of the cellular STING pool intrinsically resides in the nucleus, prevalently at the inner nuclear membrane, and interacts with the three core proteins of the DNA-PK complex (DNA-PKcs, XRCC6 and XRCC5), a master regulator of DNA damage response [141]. The gene discussed is STING1; the disease is breast carcinoma.