These signaling pathways initiate EMT programs in tumor cells through induction of a core set of EMT transcription factors including three different protein families, namely the basic helix–loop–helix factors TWIST1 and TWIST2, the zinc-finger E-box-binding homeobox factors ZEB1 and ZEB2 and the SNAIL family of zinc-finger factors SNAI1 (also known as SNAIL) and SNAI2 (also known as SLUG) [3]. This evidence concerns the gene ZEB1 and neoplasm.