Moreover, lncRNA ELIT-1, which its upregulation positively correlates with poor outcome in patients with lung adenocarcinoma and gastric cancer, interacts with Smad3 and recruits it to the promoters of multiple genes including SNAIL, vimentin, N-cadherin, API-1, and ELIT-1 itself to accelerate their transcription, forming a positive feedback loop which promotes EMT [145]. This evidence concerns the gene VIM and gastric cancer.