Moreover, circPCNXL2, which is highly expressed in clear cell renal cell carcinoma (ccRCC) and positively correlates with poor prognosis, induces invasion and proliferation in vitro and promotes tumor growth in a xenograft mouse model by acting as a miRNA sponge to inhibit the miR-153-mediated suppression of ZEB2 [155]. Here, ZEB2 is linked to neoplasm.