Added to this, a therapy-resistant ovarian cancer cell line (A2780/A2780cis) was shown to present upregulated COL1A2, COL12A1, COL21A1, LOX, TGFBI, LAMB1, EFEMP1, GPC3, SDC2, MGP, MMP3, and TIMP3 genes. The gene discussed is LOX; the disease is ovarian carcinoma.