In several studies, it was observed that COLI induces resistance to cisplatin and mitoxantrone in ER-positive cancer cells, by activating β1 integrin followed by the FAK/PI3K/AKT pathway, in triple negative cancer cells by MAPK pathway and in ovarian cancer through the co-expression of LOX with COL1A2 [188, 189]. The gene discussed is LOX; the disease is ovarian cancer.