In 2017 Chen et al. demonstrated that overexpression of AQP5 promoted the mesenchymal-like phenotype and EMT process in the high metastatic colorectal cancer cell lines (i.e. HCT-116, SW480); while, inhibition of AQP5 resulted in the inhibition of EMT in these cell lines [31]. Here, AQP5 is linked to colorectal cancer.