Considering that circGLIS3, CAPG, and GLIS3 were overexpressed in GBM tissues, we found that according to the results from FISH, RIP assay, and qRT-PCR, CAPG and GLIS3 were positively regulated by circGLIS3 and the three genes were co-localized in cell cytoplasm, implying the possibility of a ceRNA network (Fig. 2B–D). This evidence concerns the gene GLIS3 and glioblastoma.