The aim of the present study was to explore whether a genetic risk allele sum score of NT-proBNP increasing alleles (GRSNT-proBNP) may interact with indicators of SEP (i.e., education, household income) and traditional CRFs (i.e., total cholesterol, high-density lipoprotein, low-density lipoprotein, triglycerides, C-reactive protein, serum glucose, HBA1C, body mass index, blood pressure, physical activity, diabetes mellitus, smoking status and coronary artery calcification) to influence plasma levels of NT-proBNP in a population-based study sample. This evidence concerns the gene NPPB and coronary artery calcification.