Previously, we demonstrated that Ras association domain family member 6 (RASSF6) acted as a tumor suppressor in GC and after up-regulated the expression of RASSF6 in GC cells, we identified that ubiquitous mitochondrial creatine kinase (uMtCK) was significantly decreased in GC cells compared with control groups using a loss of heterozygosity (LOH) analysis and cDNA microarrays [5, 6]. Here, RASSF6 is linked to gastric cancer.