To elucidate the clinical implications of the role of CXXC5 in NASH development, we investigated the mRNA expression profiles of CXXC5 and Wnt-responsive genes in NASH patients with obesity (Supplementary Table 1) using gene set enrichment analysis (Gene Expression Omnibus (GEO): GSE48452). Here, CXXC5 is linked to obesity due to melanocortin 4 receptor deficiency.