The Wnt/β-catenin signaling pathway plays key roles in a wide range of metabolic disorders, such as inflammation, hepatic steatosis, gluconeogenesis, energy metabolism, and insulin resistance, which may be attributed to its target genes that play critical roles in metabolism, including glucagon-like peptide-1 (GLP-1), transcription factor-7-like-2 (TCF7L2), peroxisome proliferator-activated receptor delta (PPARδ), and WNT1-inducible signaling pathway protein 1 (WISP1)10. Here, CCN4 is linked to metabolic disease.