The improvement in multiple NASH phenotypes, including steatosis, ballooning, inflammation, oxidative stress, and fibrosis, by Cxxc5 knockout or KY19334 treatment could be attributed to the enhancement of the regeneration system through activation of Wnt/β-catenin signaling and subsequent induction of genes involved in regeneration and metabolism, such as Glp-1, Pparδ, and Lgr521,40,41. Here, CXXC5 is linked to metabolic dysfunction-associated steatohepatitis.