The liver tissues of the Cxxc5−/− mice, as well as those of mice administered KY19334, showed an enhanced liver regeneration system in the HFD + CCl4-induced NASH model as monitored by the measurement of the stem cell markers including EpCam, Sox9, Cd44, Prom1, and Lgr5. The induction of these multiple stem cell markers may be attributed to the activation of direct Wnt/β-catenin signaling target genes, including Lgr521,26. Here, EPCAM is linked to metabolic dysfunction-associated steatohepatitis.