The results of the microarray analyses showed that the mRNA levels of the Wnt/β-catenin signaling target genes involved in metabolism, such as TCF7L2, GLP1, AXIN2, FOSL1, and WISP1, were lower in liver tissues from NASH patients (Fig. 1a, b). This evidence concerns the gene FOSL1 and metabolic dysfunction-associated steatohepatitis.