In this study, we found that CXXC5 was specifically induced with suppressing Wnt/β-catenin pathway target genes such as GLP1, TCF7L2, WISP1, and fos-related antigen 1 (FOSL1) in the liver tissues of NASH patients with metabolic disorders. The gene discussed is CXXC5; the disease is metabolic dysfunction-associated steatohepatitis.