CCN4 and metabolic dysfunction-associated steatohepatitis: The expression of Wnt/β-catenin signaling response genes, such as Tcf7l2, Glp-1, Axin2, Fosl1, and Wisp1, which are involved in metabolic dysfunction, was lower in the liver tissues of HFD + CCl4− or HFD + GTG-induced NASH mice (Fig. 1f, g).