Various direct Wnt/β-catenin signaling target genes, including GLP1, PPARδ, TCF7L2, AXIN, and WISP1, and indirect effectors, such as PPARγ and C/EBPα, which are suppressed by WISP1, are involved in metabolic diseases and have been used as targets for the development of drugs34. This evidence concerns the gene AXIN1 and Other metabolic disease.