KEGG Pathway enrichment analysis based on the predicted target genes was also conducted, and the results were closely associated with the Circadian rhythm, TGF-beta signaling pathway, Rheumatoid arthritis, FOXO signaling pathway, Cytokine-cytokine receptor interaction, ECM-receptor interaction, MicroRNAs in cancer, focal adhesion, and PI3K-Akt signaling pathway (Fig. 2F). Here, AKT1 is linked to rheumatoid arthritis.