Specifically, researchers used RNA-Seq analysis to find that PRDM16 disrupts the transcriptome of cancer cells like semaphorin 5B (SEMA5B), which is a hypoxia-inducible factor (HIF) target gene highly expressed in RCC that promotes in vivo tumor growth.302 However, a new study has drawn the opposite conclusion that ccRCC promotes adipocyte browning to enhance tumor growth. Here, SEMA5B is linked to cancer.