DLAT and cardiovascular disorder: More specifically, they found that HPF directly targeted dihydrolipoamide S-acetyltransferase (DLAT) and thereby enhanced the capacity of heat generation by activating AMPK and PGC1A.156 However, stimulating the thermogenesis of the whole body has limited applications because of the potential risk of cardiovascular diseases and other complications caused by hypermetabolism.157,158 Thus, safer approaches to achieving beige fat activation are required.