UCP1 and cancer: Moreover, cancer cachexia has commonly been considered the main inducement of complications in patients with malignancy, leading to reduced quality of life and poor outcomes.227–230 Over the years, plenty of evidence has shown that thermogenic fat contributes to cancer cachexia owing to its key role in heat production and energy balance.231,232 Brown or beige fat is an active tissue associated with hypermetabolism because of the high presence of UCP1, which leads to thermogenesis and energetic inefficiency.