Moreover, the breast adipose tissue is impacted by surrounding cancer cells, and vice-versa modifies the TME in favor of cancer via browning of WAT.319 For example, a recent study demonstrated that markers for BAT and beige adipocytes were highly expressed in BC xenografts, implicating that thermal characteristics could play a vital role in BC progression.320 In agreement with this finding, newly published articles have suggested that BC mammospheres can secrete adrenomedullin to induce the browning of adjacent adipocytes and lipolysis. Here, ADM is linked to breast cancer.