SUCNR1 and hepatocellular carcinoma: Mechanically, increased succinate in liver tissue drives inflammation through blinding to succinate receptor 1 (SUCNR1) in liver-resident stellate cell and macrophage populations and activated thermogenic adipocytes in mice protect against SUCNR1-dependent inflammatory infiltration in the liver.293 In conclusion, thermogenic adipocytes prevent the progression of NAFLD and thereby reduce the occurrence of HCC through increasing energy expenditure and suppressing liver inflammation.