Mechanically, local hyperthermia activates heat shock factor 1 (HSF1), and enhanced HSF1 regulates Hnrnpa2b1 transcription, consequently increasing the mRNA stability of key metabolic genes.161 In conclusion, the manipulation of thermogenic activity in adipose tissue is regarded as a potential strategy in the treatment of obesity. Here, HSF1 is linked to obesity due to melanocortin 4 receptor deficiency.