Accordingly, overexpression of BMP4 in adipose tissues enhanced the thermogenic activity of PVAT and protects against atherosclerosis in mice.199 Moreover, the PVAT also secretes multiple vasorelaxant factors such as adiponectin,200 gasotransmitters hydrogen sulfide,201 nitric oxide,202 and palmitic methyl ester,203 and these vasorelaxant factors can alleviate blood pressure in the microcirculatory system. The gene discussed is ADIPOQ; the disease is atherosclerosis.