Furthermore, Y108H in the Sra1 homolog Cyfip2 (which shares 88% sequence identity with Sra1 and is analogously incorporated into a WRC) is one of the hotspot mutations found in patients with developmental and epileptic encephalopathy-65 (DEE-65)27. The gene discussed is CYFIP2; the disease is developmental and epileptic encephalopathy, 65.