Several loci that are previously well known as associated with the risk of the diseases have been identified in our study, such as the loci LPA and CELSR2 for IHD48,49, FGFR250 and CASC1651 for breast cancer, MYOC52 and TMCO153 for glaucoma, and APOE e4 variant for AD54. Here, APOE is linked to breast carcinoma.