APOE and Stroke: We identified the previously reported APOE locus for lifespan57 in FinnGen, in which the most significant variant is the APOE-e4 missense variant rs429358 (MAF = 18.3%, p-value  = \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$1.01\times {10}^{-14}$$\end{document}1.01×10−14) and it is well-known to be associated with lifespan, cardiovascular diseases, stroke, and Alzheimer’s disease58–60.