These results indicated that we successfully validate potential pleiotropic effects of the variant of ADIPOQ (c.268G>A) for the phenotype of AD/D (aggregation of tau, and the longitudinal trend of cognitive degeneration; p < 0.05), and the phenotype of CD (thickened muscle in the wall of the heart; p < 0.05) (Fig. 4A–H). Here, MAPT is linked to Alzheimer disease.