CD276 and pachyonychia congenita: To validate B7-H3 as a therapeutic target in advanced PC, we analysed two independent PC transcriptome datasets and ranked its expression in comparison to other genes in the 770-genes nCounter PanCancer Immune Profiling Panel (42) and showed that B7-H3 was among the highest expressed immune genes in the SU2C/PCF (6th centile) and RMH cohorts (8th centile).