CD276 and pachyonychia congenita: We evaluated B7-H3 mRNA expression in relation to a panel of 770 immune-related genes; compared B7-H3 protein expression between same-patient CSPC and CRPC biopsies; determined associations with PC genomic alterations; evaluated the antitumour activity of DS-7300a, a topoisomerase-1 inhibitor payload anti-B7-H3 ADC, in human PC cell lines, organoids and xenografts of different histologies, B7-H3 expressions, and genomics.