CD276 and neoplasm: Beyond its immunologic functions, B7-H3 has also been reported to increase tumour survival, stemness, chemo-resistance, and metastases through modulation of pathways such as JAK2-STAT3, MEK, PI3K/AKT, and anti-apoptotic proteins in models of colorectal, breast, ovarian, head and neck, and other cancers (19–21).