Next, we investigated the antitumour activity of a TOP1 inhibitor payload anti-B7H3 ADC (DS-7300a, Daiichi Sankyo) (24) in B7-H3-positive and negative human PC cell lines and PDX-Os of adenocarcinoma (PDX-O: CP327, CP50C; cell line: VCAP, LNCaP, 22Rv1) and neuroendocrine histology (PDX-O: CP142C; cell line: DU145, PC3) with various genomic backgrounds (Fig. 4A, B, Supplementary Table S7)(36,37). The gene discussed is CD276; the disease is adenocarcinoma.