CD276 and neoplasm: Whilst B7-H3 overexpression has previously been associated with metastases and worse outcomes (4–7), we observed no significant difference in the rate of B7-H3 positivity or the median level of expression between CSPC and CRPC in our cohort of patients who all developed mCRPC, suggesting that B7-H3 upregulation likely occurred early in the disease course of aggressive tumours.