Finally, we assessed the phagocytic activity of IM-reprogrammed TAMs as a functional component of their immunostimulatory phenotype, given that phagocytic activity has been associated with the capacity to cross-present tumor antigens to CD8+ T cells (Tseng et al., 2013, p. 47; von Roemeling et al., 2020). This evidence concerns the gene CD8A and neoplasm.