CD40 and melanoma: In addition, we observed increased expression of pro-inflammatory mediators (e.g., Icam1, Cd40, Irf7) in tumor endothelial cells from both mesenchymal and proneural GBM tumors as well as in melanoma (Figures 3J, S4J and S4K), consistent with more efficient T cell trafficking and suggestive of their contributions to potent anti-tumor immunity.