Second, imipramine reprogramed TAMs in the glioma tumor microenvironment, converting immunosuppressive microglia and MDMs into pro-inflammatory macrophages, each of which participates distinctly in the recruitment of T cells, in part by expressing the pro-inflammatory chemokines CXCL9 and CXCL10, as validated by inhibition of their receptor CXCR3. Here, CXCL9 is linked to central nervous system cancer.