CD4 and neoplasm: Noting that CD4 T cells are also capable of direct cytotoxicity against tumor cells (Oh et al., 2020, p. 4; Quezada et al., 2010), we assessed markers linked to cytotoxic function in CD4 T cells (Cachot et al., 2021), revealing higher expression of SLAMF7 and GzB within this population recruited by the dual combinatorial therapy, indicative of their cytotoxic potential (Figures 2N and 2O).