LAG3 and cancer: Concordantly, the relapsing tumors had reduced infiltration of CD8 T cells and upregulation of the T cell exhaustion markers LAG3 and EOMES (Figures 7I, 7J, S6D, and S6E), of which LAG3 is also considered a functionally important immune checkpoint in cancer (Aroldi et al., 2022, p. 3).