Noting that CD4 T cells are also capable of direct cytotoxicity against tumor cells (Oh et al., 2020, p. 4; Quezada et al., 2010), we assessed markers linked to cytotoxic function in CD4 T cells (Cachot et al., 2021), revealing higher expression of SLAMF7 and GzB within this population recruited by the dual combinatorial therapy, indicative of their cytotoxic potential (Figures 2N and 2O). The gene discussed is SLAMF7; the disease is neoplasm.