Second, imipramine reprogramed TAMs in the glioma tumor microenvironment, converting immunosuppressive microglia and MDMs into pro-inflammatory macrophages, each of which participates distinctly in the recruitment of T cells, in part by expressing the pro-inflammatory chemokines CXCL9 and CXCL10, as validated by inhibition of their receptor CXCR3. The gene discussed is CXCL10; the disease is central nervous system cancer.