CCN1 and neoplasm: Cysteine-rich angiogenic inducer 61 (CYR61 or CCN family member 1) is a cell-associated as well as secreted matricellular protein involved in tumor formation, growth, vascularization, angiogenesis, adhesion, drug resistance, migration, and invasion [[26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40]].