CCN1 and cancer: As already mentioned above, the current study demonstrates that the H2S/CyR61 interactions are not only (likely) different in different forms of cancer, but even are heterogeneous when comparing different human colon cancer cell lines. Contrary to HCT116 cells, HMPSNE significantly reduced cell-associated CyR61 protein levels in HT-29 and LoVo cells (Fig. 7A and B).