Numerous evidences indicates that AKT/mTOR signaling is frequently activated in most malignant cancers, and regulates tumor cell proliferation, adhesion, survival, migration and invasion.2,15–17 In addition, AKT phosphorylation induces tumor cell migration and invasion through degradation of the MMPs-mediated matrix.18 Therefore, we treated melanoma cells with Yoda1 (a Piezo1 activator) at 10 μM as the most effective concentration. Here, PIEZO1 is linked to cancer.