Increased tissue stiffness actively promotes malignant progression by affecting proliferation, migration, invasion, drug resistance, and growth-promoting signaling.21,22 Studies show that Piezo1 mediates breast cancer cell migration by regulating cell stiffness, contractility, and adhesiveness.10,23 In addition, Piezo1 has oncogenic effects in gastric cancer cells, including effects on cell migration, invasion and proliferation.24 In glioma, Piezo1 channels interact with integrin-FAK signaling and further promote tumor cell proliferation and tissue stiffness. The gene discussed is PTK2; the disease is gastric cancer.