Numerous evidences indicates that AKT/mTOR signaling is frequently activated in most malignant cancers, and regulates tumor cell proliferation, adhesion, survival, migration and invasion.2,15–17 In addition, AKT phosphorylation induces tumor cell migration and invasion through degradation of the MMPs-mediated matrix.18 Therefore, we treated melanoma cells with Yoda1 (a Piezo1 activator) at 10 μM as the most effective concentration. This evidence concerns the gene PIEZO1 and melanoma.