Moreover, the expression of genes including Piezo1 involved in ECM remodeling can modulate tissue stiffness.9,35 Numerous studies have suggested that EMT could contribute to invasion and metastasis in melanoma.36–38 Moreover, tumor progression is dependent on extracellular matrix remodeling, fibroblast and macrophage activation and EMT.39 Since EMT is associated with the epigenetic signature of ECM remolding genes,40 we hypothesized that the metastatic process in melanoma cells is associated with Piezo1 regulation of ECM remodeling. This evidence concerns the gene PIEZO1 and melanoma.