Different factors favor the development of anemia during progression to CKD,including reduced erythrocyte life span; reduced glutathione erythrocyte levels;folate and vitamin B deficiency caused by polyuria and insufficient intake of thesenutrients; iron deficiency due to low iron intake and gut absorption and low ironproduction levels due to erythropoietin deficit linked to kidney mass reduction34. This evidence concerns the gene EPO and nutritional disorder.