GATA1 and COVID-19: The impact of the inhibition of the inflammasome in both the S protein–induced inflammation and neutrophilia is an important observation, since dysregulated hematopoiesis has been observed in patients with severe COVID-19 (38); moreover, the canonical inflammasome regulates the erythroid/myeloid decision of hematopoietic stem and progenitor cells (HSPCs) via cleavage of the master erythroid transcription factor GATA binding protein 1 (GATA1) (39).