This CM contains cytokines, including interleukin-10, TGF-β, Hep growth factor, and vascular endothelial growth factor, which induce cell proliferation, migration, and invasion of the cancer cells (Amann et al, 2009; Badiola et al, 2012; Gentilini et al, 2012; Rombouts et al, 2013). This evidence concerns the gene TGFB1 and cancer.