CYGB and Hepatic fibrosis: In contrast, the overexpression of CYGB in HSC, either in specific Cygb transgenic mice or through recombinant CYGB injection, hampered the activation of HSC, attenuating lipid peroxidation and oxidative DNA damage in Hep and consequently suppressing liver fibrosis (Dat et al, 2021; Thi Thanh Hai et al, 2018).