The COVID Human Genetic Effort (http://www.covidhge.com; Casanova et al., 2020) found inborn errors of TLR3-dependent or -independent type I IFN immunity, including not only AR IRF7 deficiency but also AR IFNAR1 deficiency, in previously healthy patients with critical COVID-19 (Zhang et al., 2020b, 2022, Casanova and Abel, 2021b, 2022; Abolhassani et al., 2022; Campbell et al., 2022). Here, AR is linked to COVID-19.