Increased risk for cardiovascular lesions (CVD) in patients with pre-existing chronic inflammatory diseases at younger ages observed in some studies raised the assumption about endothelial dysfunction as a common initial lesion in the development of atherosclerosis [5, 17], and irisin, as a hormone-like myokine, Lee et al. demonstrated its association with endothelial dysfunctions and subclinical atherosclerosis in non-diabetic adult patients [11]. Here, FNDC5 is linked to endothelial dysfunction.