Hyperglycemia and hyperlipidaemia are known to accelerate the atherosclerotic process by direct endothelial dysfunction augmenting cytokine release with increasing lipid peroxidation and causing oxidative damage [20]; our results showed non-significant differences regarding fasting glucose, cholesterol, triglyceride, or HDL in patients and controls, which enabled us to estimate the relationship between irisin and atherosclerosis as there was no correlation. This evidence concerns the gene FNDC5 and endothelial dysfunction.