Irisin, and decreasing ankle brachial pressure index agreed with Vogt et al. [29], who stated that ABPI ratio of less than 0.9 was associated with up to a threefold relative increase in all-cause and cardiac mortality, and agreed as well with Lee et al. [11] whose results demonstrated a significant correlation between serum irisin level and carotid atherosclerosis in dialysis patients. Here, FNDC5 is linked to carotid atherosclerosis.