To gain insight into subregional diversification of oligodendrocytes and their changes in MS, we then pooled nuclear profiles from control and MS samples and identified two homeostatic oligodendrocyte subtypes (mix of nuclei from control and MS samples) characterized by specific expression of LINC01608 and SLC5A11, as well as two reactive subtypes enriched for nuclei from MS samples and characterized by expression of HSPA1A and SGCZ (Fig. 4d, e, Suppl. This evidence concerns the gene SLC5A11 and myeloid sarcoma.