Indeed, the diagnosis of ALS includes not only the characterization of clinical features, as well as results from electrodiagnostic testing, but also analysis of the four most robust and commonly ALS-associated genes, to wit: (i) C9orf72, (ii) SOD1, (iii) TARDBP and, (iv) FUS. Here, TARDBP is linked to amyotrophic lateral sclerosis.