In ALS, many genes involved in the protein degradation pathway are mutated, such as Ubiquilin-2 (UBQLN2), sequestosome 1 (SQSTM1), Optineurin (OPTN), TANK Binding Kinase 1 (TBK1), Valosin Containing Protein (VCP), and chromosome 9 open reading frame 72 (C9orf72) [2]. The gene discussed is OPTN; the disease is amyotrophic lateral sclerosis.